ABSTRACT
Background Little is known about the opinion of professional academic immunologists regarding the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Methodology In this study, we designed an online survey to determine the opinion of immunologically competent academics on SARS-CoV-2 compared with seasonal flu (the infection fatality rate, infectivity, the challenge to the health system, the importance of vaccine development, and the importance of the virulence of the virus and host factors), in addition to collecting demographic status variables and information sources used. Links to the survey were sent to all German-speaking immunologists, bacteriologists, virologists, and infectiologists in Germany, Austria, and Switzerland. Results A total of 91 full datasets were returned after three waves of requests. Approximately half of the respondents were male and half were more junior. Slightly more than half of the respondents said that the infection fatality rate and the infectivity were higher compared to flu, and 82% said that the challenge to the health system is higher. Overall, 52% found that the immune system is more important than the virus, and a majority (59%) supported the current practice of vaccination development by telescoping. A majority were of the view that conspiracy theories and non-pharmacological interventions pose a greater danger than the virus. Respondents who were more junior but well-published and mostly informed by public channels were more likely to support a mainstream view. Conclusions German-speaking immunological professionals hold widely diverging opinions regarding SARS-CoV-2. Over half of the surveyed professionals considered SARS-CoV-2 to be more dangerous and infective than the seasonal flu. However, the majority considered the health system to be under higher strain. Interestingly, more than half of them found host factors more important.